The ABE curriculum allows students to learn about core technologies used by scientists in the discovery of human therapeutics, so that they will better understand the role of biotechnology and the potential impact of this industry on our future.
Note: The teacher guides are password-protected—please contact the ABE Program Office for access.
ABE Lab Materials
The ABE labs allow students to carry out some of the important steps in the biotechnology industry to develop medicines to treat a variety of diseases. By engaging in this program, students will be more motivated to understand the underlying science concepts, develop critical laboratory skills, and be equipped to pursue future careers in science.
If students complete the full sequence of ABE labs (which takes ~3 weeks), they will produce a recombinant DNA molecule and then use it to transform E. coli.
- The ABE Student Guide is now available as an audio book.
ABE Non-Lab Materials
Students are introduced to the concept of genes which code for the traits that are expressed by organisms and examine the genetics of some familiar organisms.
Students become engaged in learning about the disease cystic fibrosis (CF): they develop questions that they have about CF, its treatment, and its consequences, and then explore how they can transform their questions into scientific questions that can be investigated. Students also examine real data to determine how CF is inherited, experiment with osmosis to explore the disease’s possible mechanism of action, and investigate transcription and translation of CFTR exons. Supporting article: H Andersen, D & G Hodges. (1946). CELIAC SYNDROMEV. Genetics of Cystic Fibrosis of the Pancreas With a Consideration of Etiology. American journal of diseases of children (1911).
Students learn that genetics is more complex than the simple binary relationship it is often portrayed as having. They explore how extreme phenotypes can be used to inform our understanding of drug development and investigate some of the cutting edge techniques being used in biotechnology today, including genome wide association studies and CRISPR-Cas9.
A man drinks an unknown liquid and soon is found unresponsive in an emergency room. Students use bioinformatics tools to investigate what substance caused such a life-threatening response.
The ABE curriculum should be used for educational purposes only.