Curriculum & Resources



In this lesson, students deepen their understanding of the relationship between scientific research in modern biology and medicine by studying the genetic basis of thalassemia, a form of hereditary anemia quite widespread in all Mediterranean countries.

Students are asked to investigate through active teaching methods the gene mutations that cause alpha and beta thalassemia using bioinformatics tools, LabXchange, and practical activities with active participation of students, through the inquiry-based methods.

They will use the molecular biology methods used to detect this blood disease as restriction enzyme digestion, PCR, and DNA electrophoresis.

Finally, evolutionary aspects of this disease and potential gene therapy techniques for thalassemia care are investigated, reflecting also on ethical issues.

These materials were developed by an ABE Master Teacher as part of the ABE Master Teacher Fellowship.

Class sessions


Resource Type
Teaching Materials
Appropriate Ages
Upper Secondary
Resource Topic
Biotech & Society